5 Fabulous Supplements for Autoimmune Conditions

When it comes to autoimmune diseases, we know that there are many root causes, and of course that means supplementation will also vary. There are 5 supplements that across the board I think are fabulous for autoimmune conditions though. These are ones I tend to lean on with clients quite often. They all help with inflammation and the unpleasant symptoms (such as pain) that many deal with regularly. As always, please check with your doctor prior to starting any new regimen.

Black seed oil

This is one of my absolute favorite supplements, and I take it daily. It tastes terrible (be forewarned), but the benefits are abundant. Black seed, which is also known as black cumin or nigella sativa, has immunomodulatory and antioxidant effects. In Islamic literature, it is considered as one of the greatest forms of healing medicine- it’s said to cure everything but death. It can help with skin, liver, and GI issues. It’s also great for those with thyroid problems as a study showed a decrease in TPO antibodies and an increase in T3 levels.


Quercetin is often used for allergies (and is great for that), but people underestimate the power of its benefits with autoimmune. It’s a powerful antioxidant that’s found in foods like blueberries, apples and tea. Quercetin can suppress NF-κB which is the inflammatory pathway, and is also shown to decrease c-reactive protein. Dr Liz Lipski also touts the benefits for gut healing in her book Digestive Wellness, since it can increase gut diversity which is often an issue with autoimmune. Want to geek out a bit more on quercetin? Check out this blog HERE which offers an abundance of information.

Ultra Clear RENEW

This supplement is from Metagenics, and is in the form of a shake to help with overall detoxification. An accumulation of toxins is associated with a number of health issues such as fatigue, gut issues, and of course, autoimmune disorders. Because we are constantly bombarded with toxins in our everyday life, it’s quite easy to become overburdened with them. This drink helps reduce the impact of processed foods and excess sugar. Additionally it provides just the right nutrients to support all 3 phases of metabolic detoxification. So if you’re dealing with any type of toxicity, this is a great supplement to incorporate.


Like quercetin and black seed oil, resveratrol contains compounds that act as antioxidants. It’s been shown to have a positive effect on those with autoimmune disease, and one study even found that it helped reduce the progression of lupus and inflammatory bowel disease. While you can get resveratrol from red wine and grapes, you also have to weigh the possibility of outside contaminates such as pesticides and mycotoxins. Beyond lowering inflammation, studies on resveratrol show some very promising neuroprotective and anti-microbial effects.


Well, you know I saved the best for last 😉 Because so many autoimmune conditions are associated with altered gut function, probiotics can be highly beneficial. While I’m always a fan of testing gut to see what’s going on, if that’s not an option, a good quality probiotic is still well worth your money. As you likely know, not all products are created equal. I suggest opting for something that you have to get through a practitioner because the quality will be higher. Some of my favorites include Megasporebiotic and Probiota HistaminX from Seeking Health.

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